Ferroptosis: Opportunities and Challenges in Cancer
نویسندگان
چکیده
Ferroptosis is a programmed cell death mainly manifested as accumulation of ferrous ions and lipid peroxidation. well regulated by multiple signaling pathways, which SLC7A11/GPX4 axis the key pathway negatively regulating ferroptosis eliminating While disorder iron homeostasis catalyzes peroxidation supplying iron. Lipid metabolism participates in offering substrates. In addition, transsulfuration FSP1/CoQ10 also involve ferroptosis. Evading one strategy that cancer bypass develop resistant to chemotherapy or radiotherapy, making inducers potential treatment for cancer. The objective this review summarize pathways inducers, thus exploring opportunities challenges inducing
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ژورنال
عنوان ژورنال: Journal of exploratory research in pharmacology
سال: 2023
ISSN: ['2572-5505']
DOI: https://doi.org/10.14218/jerp.2023.00003